AVS Bio - Platelet Derived Growth Factor Βeta, Human

SKU: P001

Description

Human PDGFb, platelet derived growth factor, is a dimeric protein. It can form homodimers of PDGFb or heterodimers with PDGFa. It is involved in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Mutations in PDGFb are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.

Research Area

Metabolism Research

Storage & Handling

• Storage: -80°C
• Form/Appearance: solution
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only