AVS Bio - Recombinant human complement factor D

SKU: D002

Description

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Residues 26-253 of human Complement factor D were cloned, the protein was over-expressed in HEK293EBNA1 cells and was purified to homogeneity. The calculated molecular weight of recombinant human complement factor D is 24.7 kDa. Each vial contains 100 µg complement factor D at 6.08 mg/ml.

Key Properties

• Protein Sequence: miparfagvllalalilpgtgsilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahslsqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapgtlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsckgdsggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvlaaa*

Storage & Handling

• Storage: Recombinant complement factor D should be stored at - 80°C (stable for at least 1 year). The protein isstored in 25 mM tris 150 mM NaCl pH 7.5. After thawing it should be stored in appropriate small aliquotsat - 20°C or - 80°C (stable for at least 2 months).
• Form/Appearance: solution
• Expiration Date: For shelf life and expiration details, please refer to the Certificate of Analysis (CoA).
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Alternative Names

D component of complement; adipsin; properdin factor D; C3 convertase activator

Quick Database Links

UniProt

P00746