AVS Bio - Recombinant human C2

SKU: C001

Description

Recombinant human complement protein C2 with an N-terminal his-tag. The cDNA of human complement component C2 (genbank NM_000063) was cloned, expressed in HEK293 and purified to homogeneity (figure 1). Each vial contains 200 µg C2 at a concentration of 0.4 mg/ml. Complement Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to be associated with certain autoimmune diseases. The gene localizes within the class III region of the MHC on the short arm of chromosome 6.

Key Properties

• Protein Sequence: marplctllllmatlagalagshhhhhhgsapscpqnvnisggtftlshgwapgslltyscpqglypspasrlckssgqwqtpgatrslskavckpvrcpapvsfengiytprlgsypvggnvsfecedgfilrgspvrqcrpngmwdgetavcdngaghcpnpgislgavrtgfrfghgdkvryrcssnlvltgsserecqgngvwsgtepicrqpysydfpedvapalgtsfshmlgatnptqktkeslgrkiqiqrsghlnlyllldcsqsvsendflifkesaslmvdrifsfeinvsvaiitfasepkvlmsvlndnsrdmtevisslenanykdhengtgtntyaalnsvylmmnnqmrllgmetmawqeirhaiilltdgksnmggspktavdhireilninqkrndyldiyaigvgkldvdwrelnelgskkdgerhafilqdtkalhqvfehmldvskltdticgvgnmsanasdqertpwhvtikpksqetcrgalisdqwvltaahcfrdgndhslwrvnvgdpksqwgkefliekavispgfdvfakknqgilefygddiallklaqkvkmstharpiclpctmeanlalrrpqgstcrdhenellnkqsvpahfvalngsklninlkmgvewtscaevvsqektmfpnltdvrevvtdqflcsgtqedespckgesggavflerrfrffqvglvswglynpclgsadknsrkraprskvppprdfhinlfrmqpwlrqhlgdvlnflpl*

Storage & Handling

• Storage: Recombinant C2 should be stored at - 80°C (stable for at least 1 year). The enzyme is stored in PBS containing 5mM benzamidin HCl at 1 mg/ml. After thawing it should be stored in appropriate small aliquots at - 20°C or- 80°C (stable for at least 2 months).
• Form/Appearance: solution
• Expiration Date: For shelf life and expiration details, please refer to the Certificate of Analysis (CoA).
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only