Ascomycin

SKU: orb1305421

Description

Ascomycin

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 104987-12-4
• MW: 729.03
• Purity: >98%
• Formula: C₄₃H₆₉NO₁₂
• SMILES: CC[C@@H]1\C=C(C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\C)=C\[C@@H]1CC[C@@H](O)[C@@H](C1)OC
• Target: PPIase
• Solubility: Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).

Bioactivity

• Target IC50:
  Calcineurin phosphatase:49 nM
• In Vivo:
  Ascomycin inhibits calcineurin by forming an FKBP12-FK520-calcineurin complex, with an IC50 of 49 nM. Additionally, FK520 accelerates neural regeneration and promotes neurite outgrowth. Ascomycin exhibits antimalarial effects by inhibiting the molecular chaperone activity of a bifunctional protein. Moreover, ascomycin suppresses the in vitro immune response of mixed lymphocytes in mice, with an IC50 of 0.55 nM.
  Read more...
• In Vitro:
  Intramuscular injection of 3.2 mg/kg Ascomycin significantly prolonged the survival rate of rats with skin transplants. When administered into the rat hippocampus, Ascomycin at concentrations of 50 or 100 μM exhibited anticonvulsant effects against seizures induced by pentylenetetrazol.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FK-520; FR-900520

Compound Identifiers

PubChem CID

5282071