Afoxolaner

SKU: orb1308871

Description

Afoxolaner is an isoxazoline-class ectoparasiticide that targets GABA and glutamate-gated chloride channels in arthropods, leading to uncontrolled neuronal excitation and death. It is widely used in veterinary research for in vivo efficacy studies against ticks like Ixodes scapularis in dogs and for in vitro investigations of insecticide mode of action.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1093861-60-9
• MW: 625.87
• Purity: 99.93% (May vary between batches)
• Formula: C₂₆H₁₇ClF₉N₃O₃
• SMILES: FC(F)(F)CNC(=O)CNC(=O)c1ccc(C2=NOC(C2)(c2cc(Cl)cc(c2)C(F)(F)F)C(F)(F)F)c2ccccc12
• Target: GABA Receptor,Parasite,Chloride channel
• Solubility: DMSO:≥ 250 mg/mL (399.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.2 mM)

Bioactivity

• In Vivo:
  A single oral administration of afoxolaner at a dose near the minimum effective (2.5mg/kg) eradicated existing I. scapularis tick infestations and managed weekly re-infestations effectively. Efficiencies ranged from 98% to 100% up to Day 23 and remained at 94% on Day 30 .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dog, Cl? Channels, Chloridechannel, Chloride Channel, Chloride channel, arthropod, Afoxolaner, acaricide, insecticide, insect, Gamma-aminobutyric acid Receptor, GABAReceptor, GABA Receptor, GABA, inhibit, Inhibitor, Ixodes, isoxazoline, Parasite, scapularis, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

25154249