Afoxolaner

SKU: orb1219112

Description

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

Key Properties

• CAS Number: 1093861-60-9
• MW: 625.87
• Purity: >98% (HPLC)
• Formula: C₂₆H₁₇ClF₉N₃O₃
• SMILES: O=C(CNC(c1ccc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)c2ccccc12)=O)NCC(F)(F)F
• Target: Chloride Channel
• Solubility: DMSO: 250 mg/mL (399.44 mM)

Bioactivity

• In Vivo:
  A single oral treatment with a dose approaching the minimum effective dose of Afoxolaner (2.5 mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Chloride Channel