Acetyl-Calpastatin(184-210)(human)

SKU: orb1679296

Description

This potent and selective calpain inhibitor exhibits high affinity for calpain I (Ki = 0.2 nM) and calpain II, while showing minimal activity against papain, trypsin, and cathepsin L. It is utilized in neuroscience research to modulate amyloid-β peptide production, specifically increasing the secretion of Aβ40, Aβ42, and the Aβ42/Aβ40 ratio in cellular models.

Research Area

Protein Biochemistry

Key Properties

• Target: Cysteine Protease
• CAS Number: 123714-50-1
• MW: 3177.65
• Formula: C₁₄₂H₂₃₀N₃₆O₄₄S
• SMILES: C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@H](CC(O)=O)NC(C)=O)=O)CCC3)CCSC)=O)CO)=O)CO)=O)[C@@H](C)O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)[C@H](C)C)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)CCC1)N4[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)=O)CCCCN)=O)CCC4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

90488788