Phospho-ASK1 (Thr845) Rabbit Polyclonal Antibody

SKU: orb6390

Description

Phospho-ASK1 (Thr845) Rabbit Polyclonal Antibody

Research Area

Cell Biology

Images & Validation

• Tested Applications: FC, WB
• Dilution Range: WB=1:500-2000, Flow-Cyt=1μg /test
• Reactivity: Human, Mouse, Rat
• Predicted Reactivity: Mouse, Rat

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: KLH conjugated Synthesised phosphopeptide derived from human ASK1 around the phosphorylation site of Thr845 TE(p-T)FT
• Target: MAP3K5
• Molecular Weight: 155 kDa
• Purification: Affinity purified by Protein A
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: 0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
• Concentration: 1mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ASK1; MAPKKK5; MEKK5; 7420452D20Rik; ASK; M3K5_HUMAN; MAP3K5; Apoptosis signal-regulating kinase 1 (ASK-1); MAPK/ERK kinase kinase 5 (MEK kinase 5 | MEKK 5); 2.7.11.25; M3K5_MOUSE; mitogen-activated protein kinase kinase kinase 5; apoptosis signal regulating kinase 1; MAP3K5 | ASK1 (phospho-T845); p-ASK1; phospho-ASK1; p-MAP3K5; MAP3K5 | ASK1 (phospho-Thr845)

Quick Database Links

Gene Symbol

MAP3K5

UniProt

Q99683

Jiaxuan He 1 2, Siyuan Li 1, Yunpeng Teng 1, Hongfei Xiong 1, Zhuang Wang 1, Xiaoyao Han 1, Wei Gong 2, Ya Gao Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway Autoimmunity, 57, 2345919 (2024)

PubMed: 38721693

Applications

WB

Reactivity

Mouse

Chiara Imarisio, Elisa Alchera, Chandrashekar Bangalore Revanna, Guido Valente, Antonia Follenzi, Elena Trisolini, Renzo Boldorini, Rita Carini Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury Free Radical Biology and Medicine, 112, 141 (2017)

PubMed: 28739531

Applications

IHC, WB

Reactivity

Mouse