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Product Overview
Product Name PGC1 alpha antibody
Catalog Number orb13647
Species/HostRabbit
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
Custom conjugations
Tested applicationsWB
Immunogen KLH conjugated synthetic peptide derived from human PGC1 alpha. Please contact us for the exact immunogen sequence. The peptide is available as orb374773.
Target PGC1 alpha
Alternative Names
Product Properties
Form/Appearance 10 mM PBS, 0.02% sodium azide
Concentration - 100 μg (in 200 μl): 0.5 mg/ml
- 200 μg (in 400 μl): 0.5 mg/ml
Storage Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Note For research use only.
Isotype IgG
ClonalityPolyclonal
Purity Polyclonal antibodies are purified by peptide affinity chromatography
MW 91 kDa
Uniprot ID Q9UBK2 (Human); O70343 (Mouse); Q9QYK2 (Rat)
NCBI NP_037393.11; NM_013261.31
Entrez 10891
Product Description

PGC1 alpha also known as PPARGC1A (PPARG Coactivator 1 Alpha) it is a Protein Coding gene. Diseases associated with PPARGC1A include Obesity and Lipomatosis. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Circadian rythm related genes. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PPRC1. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Application Notes
Dilution Range WB: 1:200-1000
Validation Images
Western blot analysis of rat heart (lane 1), mouse skeletal muscle (lane 2), rat testis (lane 3), mouse colon (lane 4), rat thymus (lane 5), mouse liver (lane 6) tissue using anti-PGC1 alpha antibody (0.5 ug/ml)
Western blot analysis of rat heart (lane 1), mouse skeletal muscle (lane 2), rat testis (lane 3), mouse colon (lane 4), rat thymus (lane 5), mouse liver (lane 6) tissue using anti-PGC1 alpha antibody (0.5 ug/ml)
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