PF-5274857

Catalog Number: orb573014

Catalog Number	orb573014
Category	Small Molecules
Description	PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
CAS Number	[1373615-35-0]
MW	436.96
SMILES	O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O
Formula	C₂₀H₂₅ClN₄O₃S
Note	For research use only
Expiration Date	12 months from date of receipt.

PF-5274857 freebase [orb1218884]
Purity:
> 98% (HPLC)
CAS Number:
1373615-35-0
Sizes Available: 50 mg, 25 mg, 100 mg, 10 mg, 5 mg, 2 mg, 1 g, 500 mg, 200 mg
PF-5274857 [orb1301768]
Purity:
98.99%
CAS Number:
1373615-35-0
MW:
436.96
Formula:
C₂₀H₂₅ClN₄O₃S
Sizes Available: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg
PF-5274857 [orb1898296]
CAS Number:
1373615-35-0
Sizes Available: 25 mg
PF-5274857 [orb1898298]
CAS Number:
1373615-35-0
Sizes Available: 10 mg
PF-5274857 [orb1898297]
CAS Number:
1373615-35-0
Sizes Available: 10mM x 1 ml in DMSO