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PF-06424439
Catalog Number: orb1089570
| Catalog Number | orb1089570 |
|---|---|
| Category | Small Molecules |
| Description | PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1. PF-06424439 demonstrated excellent ADMET properties and decreased circulating and hepatic lipids when orally administered to dyslipidemic rodent models. PF-06424439 inhibited DGAT2 of different species (human, rat, and dog) with similar potency. Among related acyltransferases, no significant inhibition was observed for PF-06424439 (up to 50 μM) against human MGAT2 or MGAT3, DGAT1, or mouse MGAT1, indicating a high selectivity (>2000-fold) against these enzymes. |
| CAS Number | [1469284-78-3] |
| MW | 439.9411 |
| SMILES | ClC1C([H])=NN(C=1[H])C1(C2=NC3=C(C([H])=C([H])C(=N3)N3C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=O)C3([H])[H])N2[H])C([H])([H])C1([H])[H] |
| Formula | C22H26CLN7O |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
PF-06424439 methanesulfonate [orb1309264]
99.77%
1469284-79-4
536.05
C23H30ClN7O4S
10 mg, 25 mg, 100 mg, 1 mg, 5 mg, 50 mg, 1 ml x 10 mm (in DMSO)
