Pexiganan

• Catalog Number: orb1140602
• Category: Proteins
• Description: Broad spectrum antibacterial agent; Antimicrobial peptides.
• CAS Number: 147664-63-9
• Modifications: C terminal amide.
• Structure: H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
• Target Areas: Antibacterials
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2477.21 Da
• Formula: C₁₂₂H₂₁₀N₃₂O₂₂
• Solubility (25°C): Soluble in DMSO and physiological buffers
• Protein Sequence: H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: 147664-63-9, AM 310AM310, GIGKFLKKAKKFGKAFVKILKK-N
• Background: Pexiganan (MSI 78) is a synthetic cationic peptide and an analogue of magainin 2, the host defence peptide isolated from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many gram-positive and gram-negative, anaerobic and aerobic bacteria and is the first AMP developed into an antibacterial drug and the best-studied AMP to date for therapeutic purposes. Pexiganan shows a barrel-stave type mechanism of membrane disruption or channel formation and exerts its antibacterial effect by forming toroidal pores in bacterial membranes.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Structure for Pexiganan