PACAP (1-38) Human, Ovine Rat peptide

• Catalog Number: orb216753
• Category: Proteins
• Description: PACAP (1-38) Human, Ovine Rat peptide
• CAS Number: 124123-15-5
• Form/Appearance: Lyophilized powder
• Purity: > 95%
• MW: 4534.36
• Formula: C₂₀₃H₃₃₁N₆₃O₅₃S
• Protein Sequence: H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
• Source: Synthetic
• Storage: Shipped at 4°C. Store at -20°C for one year.
• Alternative names: adenylate cyclase activating polypeptide 1 (pituit
• Note: For research use only
• Application notes: Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
• Expiration Date: 12 months from date of receipt.