OP-145

• Catalog Number: orb1479256
• Category: Proteins
• Description: Antimicrobial peptide derived from LL-37; Antibacterial; Antimicrobial peptides.
• CAS Number: 732984-81-5
• Modifications: N terminal acetyl, C terminal amide.
• Structure: Ac-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2
• Target Areas: Antibacterials
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 3093.77 Da
• Formula: C₁₄₂H₂₄₆N₄₆O₃₁
• Solubility (25°C): Soluble in water
• Protein Sequence: Ac-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: P60.4Ac
• Background: OP-145 is a synthetic antimicrobial peptide derived from amino acid sequence 13-36 of human cathelicidin LL-37, further modified to favour the formation of an amphipathic helix. To improve stability against proteolytic degradation, the N-terminus is acetylated and the C-terminus amidated. OP-145 is a potent antibacterial, only lytic to human cells at high concentrations, and shows significant activity against nine methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing their growth and biofilm formation. OP-145 is safe and effective against chronic middle ear infection (otitis media) in humans, and when formulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, OP-145 exerts strong anti-biofilm effects on clinical isolated pathogens and exerts powerful anti-infection effects in vivo.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.