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OGN/Osteoglycin Protein, Human, Recombinant (His)
Catalog Number: orb1954871
| Catalog Number | orb1954871 |
|---|---|
| Category | Proteins |
| Description | OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epithelial-mesenchymal transition. In vitro and in vivo, the OGN expression was demonstrated to reduce cell proliferation, inhibit invasion of colon cancer cells then impede cancer progression. Diseases associated with OGN include Inhibited Male Orgasm and Cornea Plana. |
| Tag | C-His |
| Purity | 98.00% |
| UniProt ID | P20774 |
| MW | 33.2 kDa (predicted) |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epithelial-mesenchymal transition. In vitro and in vivo, the OGN expression was demonstrated to reduce cell proliferation, inhibit invasion of colon cancer cells then impede cancer progression. Diseases associated with OGN include Inhibited Male Orgasm and Cornea Plana. |
| Expression Region | A DNA sequence encoding the human OGN (NP_054776.1) (Met1-Phe298) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Pro 21 |
| Storage | -20°C |
| Note | For research use only |
Recombinant Human OGN Protein, N-His [orb2836229]
> 90% as determined by SDS-PAGE.
15.92 kDa
100 μg, 50 μg, 20 μg
