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Oclacitinib maleate
Catalog Number: orb2647042
| Catalog Number | orb2647042 |
|---|---|
| Category | Small Molecules |
| Description | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nM. |
| MW | 453.512583017349 |
| CAS Number | [1208319-27-0] |
| Formula | C19H27N5O6S |
| SMILES | S(CC1CCC(CC1)N(C)C1C2C=CNC=2N=CN=1)(NC)(=O)=O.OC(/C=C\C(=O)O)=O |
| Note | For research use only |
Oclacitinib maleate [orb1300351]
99.17%
[1640292-55-2]
453.51
C15H23N5O2S·C4H4O4
100 mg, 50 mg, 25 mg, 10 mg, 5 mg, 2 mg, 1 mg, 1 ml x 10 mM (in DMSO)
