Oclacitinib maleate

• Catalog Number: orb2647042
• Category: Small Molecules
• Description: Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nM.
• CAS Number: [1208319-27-0]
• MW: 453.512583017349
• SMILES: S(CC1CCC(CC1)N(C)C1C2C=CNC=2N=CN=1)(NC)(=O)=O.OC(/C=C\C(=O)O)=O
• Formula: C₁₉H₂₇N₅O₆S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.