NRN1 Protein, Human, Recombinant (His)

Catalog Number: orb1957108

Catalog Number	orb1957108
Category	Small Molecules
Description	NRN1 Protein, Human, Recombinant (His)
Purity	98.00%
MW	11 kDa (predicted)
Biological Activity	Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus, neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical, neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats, and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for therapeutic intervention in the management of neuropathy.
Note	For research use only
Expiration Date	12 months from date of receipt.

Recombinant Human Neuritin/NRN1 Protein, His Tag [orb1551971]
Purity:
≥90% as determined by SDS-PAGE
Source:
This protein contains the human NRN1(Ala28-Gly116) was fused with the N-terminal His Tag and expressed in E. coli.
Sizes Available: 100 μg, 50 μg
Human Neuritin protein (N-His) [orb311911]
Source:
E.coli
Sizes Available: 1 mg, 500 μg, 50 μg, 10 μg
Human NRN1 (His) Protein [orb427406]
Sizes Available: 1 mg, 10 μg, 2 μg

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the human NRN1(Ala28-Gly116) was fused with the N-terminal His Tag and expressed in E. coli.