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NRBF2 Protein, Human, Recombinant (His & GST)
Catalog Number: orb1959094
| Catalog Number | orb1959094 |
|---|---|
| Category | Proteins |
| Description | NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. NRBF2, a key component, and regulator of the PtdIns3K has been involved in APP-CTFs homeostasis in Alzheimer's disease (AD) cell models. NRBF2 plays an important role in regulating the degradation of APP-CTFs through modulating autophagy. |
| Tag | His, GST |
| Purity | 98.00% |
| UniProt ID | Q96F24 |
| MW | 60.2 kDa (predicted); 61 kDa (reducing conditions) |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expression System | Baculovirus Insect Cells |
| Biological Origin | Human |
| Biological Activity | NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. NRBF2, a key component, and regulator of the PtdIns3K has been involved in APP-CTFs homeostasis in Alzheimer's disease (AD) cell models. NRBF2 plays an important role in regulating the degradation of APP-CTFs through modulating autophagy. |
| Expression Region | A DNA sequence encoding the human NRBF2 (Q96F24-1) (Met1-Asn287) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met |
| Storage | -20°C |
| Note | For research use only |
