NRBF2 Protein, Human, Recombinant (His & GST)

• Catalog Number: orb1959094
• Category: Small Molecules
• Description: NRBF2 Protein, Human, Recombinant (His & GST)
• Purity: 98.00%
• MW: Approxiamtely 60.2 kDa
• Biological Activity: NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. NRBF2, a key component, and regulator of the PtdIns3K has been involved in APP-CTFs homeostasis in Alzheimer's disease (AD) cell models. NRBF2 plays an important role in regulating the degradation of APP-CTFs through modulating autophagy.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.