Nitroxoline

SKU: orb1225113

Description

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

Key Properties

• CAS Number: 4008-48-4
• MW: 190.16
• Purity: >98% (HPLC)
• Formula: C₉H₆N₂O₃
• SMILES: OC1=C2C(C=CC=N2)=C([N+]([O-])=O)C=C1
• Target: Fe2+/Zn2+ ions
• Solubility: Water: 2.73 g/L

Bioactivity

• In Vivo:
  Animal model: C3H/He mice bladder injected with MBT-2 cells. Dosage: 15 mg/kg or 60 mg/kg. Administration: Orally gavage; five times a week on days 1, 2, 4, 5, 7, 8, 10, and 11. Result: Resulted in significant inhibition of tumor growth.
• In Vitro:
  Cell Viability Assay Cell line: H446, H1882, H1417, and H1688 cells. Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM Incubation time: 24 hours. Result: Effectively inhibit cell survival of small-cell lung cancer (SCLC) cells. Western blot analysis. Cell line: H446, H1882, H1417 cells. Concentration: 5 μM, 10 μM, 20 μM. Incubation time: 24 hours. Result: Suppressed antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulated proapoptotic protein Bim.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol

Quick Database Links

Gene Symbol

Fe2+/Zn2+ ions