NFKB1 Antibody

• Catalog Number: orb1731774
• Category: Antibodies
• Description: <span style="font-family:arial, helvetica, clean, sans-serif;font-size:13px;background-color:#FFFFFF;">This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 5E3E4
• Tested applications: WB
• Reactivity: Human, Mouse, Rat
• Isotype: Mouse IgG1
• Immunogen: Recombinant human NF-κB1 p105/p50 protein.
• Concentration: 1mg/ml
• Dilution range: WB: 1/500
• Conjugation: Unconjugated
• MW: 50kDa/105kDa
• Entrez: 4790
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.03% Proclin 300, pH 7.3
• Alternative names: p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB
• Note: For research use only
• Expiration Date: 12 months from date of receipt.