Moxonidine hydrochloride

• Catalog Number: orb1690286
• Category: Small Molecules
• Description: Moxonidine hydrochloride
• Purity: 98.00%
• MW: 278.14
• Biological Activity: Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant preference for I1 imidazoline receptors over α2-adrenoceptors, with a 40-fold higher affinity. This compound effectively reduces stimulated norepinephrine overflow, indicating its potent efficacy. Despite similar agents like AGN192403 targeting the same receptor, moxonidine's dose-response efficacy remains unaffected. Its ability to lower blood pressure and reduce heart rate is distinctly mediated through imidazoline receptors, reliant on well-preserved noradrenergic pathways within the rostral ventrolateral medulla (RVLM). This interaction is potentially linked to a specific 42 kDa imidazoline receptor protein, emphasizing its unique mechanism of action compared to other drugs like clonidine.
• CAS Number: [75536-04-8]
• Formula: C₉H₁₃Cl₂N₅O
• SMILES: Cl.ClC=1N=C(N=C(OC)C1NC2=NCCN2)C
• Storage: -20°C
• Note: For research use only