You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb334930 |
---|---|
Category | Proteins |
Description | Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. |
Reactivity | Mouse |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 21.0 kDa |
Target | TIM-3 |
Protein Sequence | Arg 20 - Arg 191 |
Source | Mouse TIM-3, His Tag (orb334930) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1). |
Expression System | HEK293 |
Expression Region | Arg 20 - Arg 191 |
Endotoxins | 1.0 EU per μg |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.0 kDa. The protein migrates as 33-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse TIM-3 protein
Unconjugated | |
90% | |
45.8 kDa | |
Mouse TIM-3, Fc Tag (orb334929) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1). |
≥90% as determined by SDS-PAGE | |
This protein contains the mouse Tim-3(Leu22-Ala193) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
≥90% as determined by SDS-PAGE | |
This protein contains the mouse Tim-3(Arg20-Arg191) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
Filter by Rating