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Mouse TIM-3 / HAVCR2 Protein
Catalog Number: orb334929
| Catalog Number | orb334929 |
|---|---|
| Category | Proteins |
| Description | Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. |
| Reactivity | Mouse |
| Tag | C-Fc |
| Form/Appearance | Powder |
| Purity | 90% |
| Conjugation | Unconjugated |
| MW | 45.8 kDa |
| Target | TIM-3 |
| Protein Sequence | AAL65156.1 |
| Source | Mouse TIM-3, Fc Tag (orb334929) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1). |
| Expression System | HEK293 |
| Expression Region | Arg 20 - Arg 191 |
| Endotoxins | 1.0 EU per μg |
| NCBI | AAL65156.1 |
| Storage | -20℃ |
| Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
| Alternative names | HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 Read more... |
| Note | For research use only |
| Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.8 kDa. The protein migrates as 60-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse TIM-3 protein
- Item 1 of 1
Mouse TIM-3 / HAVCR2 Protein [orb334930]
Unconjugated
95%
21.0 kDa
Mouse TIM-3, His Tag (orb334930) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1).
1 mg, 100 μg 
Recombinant Mouse TIM-3/Havcr2 Protein, His Tag [orb1551536]
≥90% as determined by SDS-PAGE
This protein contains the mouse Tim-3(Leu22-Ala193) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Mouse TIM-3/Havcr2 Protein, His Tag [orb1551540]
≥90% as determined by SDS-PAGE
This protein contains the mouse Tim-3(Arg20-Arg191) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μg
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