MLKL antibody

• Catalog Number: orb229539
• Category: Antibodies
• Description: Rabbit polyclonal antibody to MLKL also known as hMLKL whose expression can be detected in the adult and fetal brain and kidney but is highly expressive in renal tubules and testis. It is found in the cytoplasm. This protein plays an efficient role in TNF-induced necroptosis, a programmed cell death process and is activated following phosphorylation by RIPK3 leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. It does not have protein kinase activity.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: IHC-P, WB
• Reactivity: Human, Mouse, Rat
• Dilution range: WB: 1:500-2000, IHC-P: 1:50-200
• Conjugation: Unconjugated
• Alternative names: anti-9130019I15Rik antibody
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Guida, Natascia et al. The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death Biochem Pharmacol, 142, 229-241 (2017)

PubMed: 28676433

Western blot analysis of THP-1 cell line using MLKL antibody