MG 132

• Catalog Number: orb1140579
• Category: Proteins
• Description: Inhibits the chymotrypsin like activity of the 20S proteasome; Peptides.
• CAS Number: 133407-82-6
• Modifications: N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal.
• Structure: Z-Leu-Leu-Leu-CHO
• Target Areas: Proteasome
• Form/Appearance: Freeze dried solid
• Purity: > 98% by HPLC
• MW: 475.63 Da
• Formula: C₂₆H₄₁N₃O₅
• Solubility (25°C): Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL)
• Protein Sequence: Z-Leu-Leu-Leu-CHO
• Storage: Store desiccated, frozen and in the dark
• Alternative names: 133407-82-6, 20S proteasome, MG 132PI030 , Z-LLL-a
• Background: MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-α-induced NF-κB activation and IκBα degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.