Meropenem

SKU: orb1310817

Description

Meropenem is a broad-spectrum carbapenem antibiotic used intravenously for serious bacterial infections. It is a valuable research tool for in vitro susceptibility testing and in vivo infection model studies. Transient liver enzyme elevations are common, with rare instances of cholestatic liver injury reported.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 96036-03-2
• MW: 383.46
• Purity: 96.62% (May vary between batches)
• Formula: C₁₇H₂₅N₃O₅S
• SMILES: C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1S[C@H]3C[C@@H](C(N(C)C)=O)NC3)[H]
• Target: Antibacterial,Antibiotic
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.43 mM);H2O:5 mg/mL (13.04 mM);DMSO:100 mg/mL (260.78 mM)

Bioactivity

• Target IC50:
  N. gonorrhoeae:0.02-0.06 mg/mL (MIC)|H. influenzae:0.03-0.12 mg/mL (MIC)|H. ducreyi:0.015-0.12 mg/mL (MIC)|E. coli:0.19 µg/mL (MIC)|K. pneumoniae isolates:⩽ 32 mg/L (MIC)
• In Vivo:
  Meropenem exhibits an antibacterial spectrum similar to that of imipenem, but demonstrates slightly lower activity against Staphylococcus aureus and Enterococcus. It possesses enhanced activity against Pseudomonas aeruginosa, all Enterobacteriaceae, and Haemophilus influenzae. Meropenem's antimicrobial efficacy against Gram-negative organisms is two to four times greater than that of imipenem, and it has a broader spectrum in comparison to all other tested agents. Furthermore, Meropenem exhibits an antagonistic effect when combined with several beta-lactam antibiotics against strain-producing type I cephalosporins. It binds most effectively to the penicillin-binding proteins 2 of Escherichia coli and Pseudomonas aeruginosa, and to the penicillin-binding protein 1 of Staphylococcus aureus.
• In Vitro:
  Meropenem significantly increases the urinary excretion of valproate-glucuronide in rabbits.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SM 7338, SM7338, SM-7338, β-lactamases, β-Lactamase, Gram-negative, Gram-positive, Meropenem, Inhibitor, parenteral, neutropenia, inhibit, Antibiotic, anaerobic, Bacterial, D-alanyl-D-alanine carboxypeptidase DacB, DHP-1, carbapenem

Compound Identifiers

PubChem CID

57921071