Magainin 1

• Catalog Number: orb1147092
• Category: Proteins
• Description: Broad spectrum antimicrobial; Antimicrobial peptides.
• CAS Number: 108433-99-4
• Form/Appearance: Freeze dried solid
• Purity: > 95% by HPLC
• MW: 2409.8 Da
• Formula: C₁₁₂H₁₇₇N₂₉O₂₈S
• Structure: H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH
• Solubility (25°C): Soluble in dilute acid
• Protein Sequence: GIGKFLHSAGKFGKAFVGEIMKS
• Storage: Store frozen and desiccated in the dark
• Alternative names: , 108433-99-4, AM-100, AM100, African clawed frog
• Background: Magainin 1 is a 23 amino acid amphipathic cationic peptide with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainin 1 (and Magainin 2) are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2 (HSV 1 and 2).
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Structure for Magainin 1