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Langerin Antibody / CD207
Catalog Number: orb1824041
| Catalog Number | orb1824041 |
|---|---|
| Category | Antibodies |
| Description | Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the Langerin antibody. |
| UniProt ID | Q9UJ71 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Antibody Type | Primary Antibody |
| Clone Number | LGRN/7430 |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This Langerin antibody is available for research use only. |
| Note | For research use only |
IHC staining of FFPE human skin tissue with Langerin antibody (clone LGRN/7430). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human skin tissue with Langerin antibody (clone LGRN/7430). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human skin tissue with Langerin antibody (clone LGRN/7430). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Langerin antibody (clone LGRN/7430) as confirmation of integrity and purity.
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