L-654284

• Catalog Number: orb2695520
• Category: Small Molecules
• Description: L-654284 is an α2-adrenergic receptor antagonist characterized by its notable selectivity. It competes with 3H-clonidine and 3H-rauwolscine for binding in vitro, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 effectively blocks the pre-ejaculatory effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. The compound demonstrates significant selectivity for α2 over α1 adrenergic receptors, with a Ki value of 110 nM against 3H-prazosin binding. In vivo, L-654284 significantly increases the turnover of norepinephrine in the rat cerebral cortex, indicating its activity in blocking α2-adrenergic receptors within the central nervous system.
• MW: 364.46
• CAS Number: 98719-20-1
• Formula: C₁₈H₂₄N₂O₄S
• SMILES: N(S(CCO)(=O)=O)(C)[C@H]1C[C@]2(C3=C(C=4C(O3)=CC=CC4)CCN2CC1)[H]
• Storage: -20°C
• Note: For research use only