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Kindlin-1 Antibody / KIND1
Catalog Number: orb699654
| Catalog Number | orb699654 |
|---|---|
| Category | Antibodies |
| Description | Kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) is an important component of cell-extracellular matrix adhesion. Kindlin-1 is involved in cell adhesion, possibly via its interaction with integrins and may mediate TGF-beta 1 signaling during tumor progression. Kindlin-1 has been shown to be significantly upregulated in lung and colon carcinomas. Mutations in the kindlin-1 gene, FERMT1, causes Kindler syndrome. Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal pigmentation and fragility of the skin. We have developed monoclonal anti-kidlin-1 antibodies. This monoclonal antibody recognizes kindlin-1 in multiple assays including Western blotting, immunoprecipitation, immunohistochemical and immunofluorescent staining. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Amino acids 216-677 from the human protein were used as the immunogen for the Kindlin-1 antibody. |
| UniProt ID | Q9BQL6 |
| Tested applications | IHC-P, WB |
| Dilution range | Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT |
| Application notes | Optimal dilution of the Kindlin-1 antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | 4A5.14 |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This Kindlin-1 antibody is available for research use only. |
| Note | For research use only |
IHC staining of FFPE human liver with Kindlin-1 antibody (clone 4A5.14). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Kindlin-1 antibody (clone 4A5.14) as confirmation of integrity and purity.
