KDM7 (C) Antibody, Rabbit Polyclonal

SKU: orb67004

Description

Rabbit polyclonal to KDM7.Lysine-specific histone demethylase 7 (KDM7) is a histone demethylase required for braindevelopment. KDM7 specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 andH3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue(H4K20Me1), thereby playing a central role in histone code. KDM7 specifically binds trimethylated'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3,it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2.

Research Area

Epigenetics

Images & Validation

• Tested Applications: IP, WB
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human KDM7
• Molecular Weight: 107
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-KDM7 antibody

Western blot analysis of total cell extracts from mouse brain(Lane1),human Hela(Lane2) and human Jurkat(Lane3) using KDM7 antibody

Quick Database Links

UniProt

Q6ZMT4

References

Liying Shan # 1, Xiaoli Yang # 1, Xiaoxia Liao 1, Zheng Yang 2, Jie Zhou 3, Xiaoxia Li 4, Baoli Wang Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation Cell Death Dis ., 15(2), 136 (2024)

PubMed: 38346941

Applications

ChIP

Reactivity

Mouse