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JH-X-119-01
Catalog Number: orb1089899
| Catalog Number | orb1089899 |
|---|---|
| Category | Small Molecules |
| Description | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
| CAS Number | [2227368-54-7] |
| MW | 452.474 |
| SMILES | O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3 |
| Formula | C25H20N6O3 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
JH-X-119-01 [orb1298286]
97.10%
2227368-54-7
452.46
C25H20N6O3
25 mg, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 2 mg, 1 ml x 10 mm (in DMSO)
