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JAK2 antibody

Catalog Number: orb318917

DispatchUsually dispatched within 5-10 working days
$ 337.00
Catalog Numberorb318917
CategoryAntibodies
DescriptionRabbit polyclonal antibody to JAK2 also known as JAK-2 whose expression can be detected in whole-body tissues ubiquitously. It is found in the extrinsic component of the nucleus. It can perform various functions like MAPK cascade mechanism and histone H3-Y41 phosphorylation. In the nucleus it plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes the exclusion of CBX5 (HP1 alpha) from chromatin. In the cytoplasm, it plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins.
Species/HostRabbit
ClonalityPolyclonal
Tested applicationsIF, IH, WB
ReactivityHuman, Mouse, Porcine, Primate, Rabbit, Rat
ImmunogenKLH-conjugated synthetic peptide encompassing a sequence within the center region of human JAK2. The exact sequence is proprietary.
Dilution rangeWB: 1:500-1000, IHC-P: 1:100-200, IF/ICC: 1:100-500
Form/AppearanceLiquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
ConjugationUnconjugated
TargetJAK2
Entrez24514, 16452, 3717
UniProt IDQ62120, Q62689, O60674
SourceRabbit
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
Buffer/PreservativesLiquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Alternative namesanti-Tyrosine-protein kinase JAK2 antibody, anti-J
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NoteFor research use only
Expiration Date12 months from date of receipt.

Immunofluorescense analysis of Jurkat cells using JAK2 antibody

Western blot analysis of JAK2 expression in Jurkat (Lane 1), K562 (Lane 2), HEK293T (Lane 3) whole cell lysates using JAK2 antibody

Immunohistochemical analysis of formalin-fixed and paraffin-embedded human breast cancer tissue using JAK2 antibody

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