Indoxyl Sulfate-d5 potassium salt

• Catalog Number: orb1739167
• Category: Small Molecules
• Description: Indoxyl Sulfate-d5 potassium salt
• Purity: 98.00%
• MW: 256.3278
• Biological Activity: Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.
• CAS Number: 1644451-34-2
• Formula: C₈HD₅KNO₄S
• SMILES: [K+].[2H]c1[nH]c2c([2H])c([2H])c([2H])c([2H])c2c1OS([O-])(=O)=O
• Storage: -20°C
• Note: For research use only