IL17A antibody

• Catalog Number: orb48920
• Category: Antibodies
• Description: Rabbit polyclonal to IL17A.IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kB pathways.
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Isotype: IgG
• Immunogen: Recombinant fusion protein of human IL17A(NP_002181.1).
• Dilution range: WB 1:500 - 1:2000, IF/ 1:50 - 1:200
• Conjugation: Unconjugated
• MW: 18-25KDa
• UniProt ID: Q16552
• Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Buffer/Preservatives: PBS with 0.05% proclin300,50% glycerol,pH7.3.
• Alternative names: anti IL17A antibody, anti CTLA8 antibody, anti IL-
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Zhang, Xu et al. Differential Health Effects of Constant versus Intermittent Exposure to Formaldehyde in Mice: Implications for Building Ventilation Strategies Environ Sci Technol, 52, 1551-1560 (2018)

PubMed: 29293324

Immunofluorescence analysis of L929 cells using IL17A antibody.

Western blot analysis of THP-1 cells using IL17A antibody