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IL-7 Protein, Human, Recombinant (His)
Catalog Number: orb1962154
| Catalog Number | orb1962154 |
|---|---|
| Category | Proteins |
| Description | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Tag | C-6xHis |
| Purity | > 99.9% |
| Protein Sequence | Asp26-His177 |
| UniProt ID | P13232 |
| MW | 19-30 KDa (reducing condition) |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Expression Region | Asp26-His177 |
| Storage | -20°C |
| Note | For research use only |
- Item 1 of 2
Recombinant human IL-7R Alpha / CD127 protein, C-His (HEK293) [orb1516415]
> 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC
Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
100 μg, 50 μg - Item 1 of 1
Recombinant human IL-7R Alpha / CD127 protein, His (HEK293) [orb1516641]
> 95% as determined by SDS-PAGE
40-70 kDa
100 μg, 500 μg Recombinant Human CD127/IL7R Protein, N-His [orb2836318]
> 90% as determined by SDS-PAGE.
23.71 kDa
100 μg, 50 μg, 20 μgRecombinant Human CD127/IL7R Protein, C-His [orb2834284]
> 90% as determined by SDS-PAGE.
28.31 kDa
100 μg, 50 μg, 20 μgRecombinant Human IL7 Protein, C-His [orb2831935]
> 90% as determined by SDS-PAGE.
18.64 kDa
100 μg, 50 μg, 20 μg
