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Catalog Number | orb758842 |
---|---|
Category | Antibodies |
Description | Rat monoclonal antibody to IL-6R |
Species/Host | Rat |
Clonality | Monoclonal |
Clone Number | D7715A7 |
Tested applications | Blocking, FC |
Reactivity | Mouse |
Isotype | IgG2b |
Immunogen | This antibody was raised by immunising Lewis rats with OKT4 cells. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | IL-6R |
UniProt ID | P22272 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | CD126; 15A7; IL-6Ra; IL6R; Interleukin-6 receptor Read more... |
Note | For research use only |
Application notes | This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001). |
Expiration Date | 12 months from date of receipt. |
Unconjugated | |
95% | |
39.4 kDa | |
Human IL-6 R alpha, His Tag (orb257625) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 365 (Accession # NP_000556.1). |
Unconjugated | |
95% | |
65.0 kDa | |
Human IL-6 R alpha, Fc Tag (orb570285) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 365 (Accession # P08887-1). |
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