You have no items in your shopping cart.
Cart summary
IL-33 Protein, Mouse, Recombinant
Catalog Number: orb1961125
| Catalog Number | orb1961125 |
|---|---|
| Category | Proteins |
| Description | Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. |
| Tag | Tag Free |
| Purity | SDS-PAGE: 96.3%; SEC-HPLC: 95% |
| Protein Sequence | Ser109-Ile266 |
| UniProt ID | Q8BVZ5 |
| MW | 18 KDa (reducing condition) |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | E. coli |
| Biological Origin | Mouse |
| Biological Activity | Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. |
| Expression Region | Ser109-Ile266 |
| Storage | -20°C |
| Note | For research use only |
- Item 1 of 1
Mouse IL33 protein (Active) [orb359021]
> 98% as determined by SDS-PAGE and HPLC.
17.5 kDa
E.Coli
10 μg, 100 μg, 500 μg - Item 1 of 1
Mouse Il33 protein [orb594779]
Greater than 95% as determined by SDS-PAGE.
17.6 kDa
E.coli
10 μg, 50 μg, 1 mg, 500 μg Mouse IL33 protein [orb391980]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
E. coli
50 μg, 500 μg, 10 μg- Item 1 of 1
Mouse IL33 protein [orb80084]
FA, HPLC, SDS-PAGE
Unconjugated
> 97.0% as determined by RP-HPLC and analysis by SDS-PAGE
10 μg, 100 μg, 500 μg
