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IL-31 Protein, Human, Recombinant

IL-31 Protein, Human, Recombinant

Catalog Number: orb1962166

DispatchUsually dispatched within 5-10 working days
$ 290.00
Catalog Numberorb1962166
CategoryProteins
DescriptionHuman Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
TagTag Free
Purity98.00%
Protein SequenceSer24-Thr164
UniProt IDQ6EBC2
MW15 KDa (reducing condition)
Application notesReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Expression SystemE. coli
Biological OriginHuman
Biological ActivityHuman Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
Expression RegionSer24-Thr164
Storage-20°C
NoteFor research use only
  • Human IL31 protein (Active) [orb358986]

    > 97% as determined by SDS-PAGE and HPLC.

    15.8 kDa

    E.Coli

    500 μg, 100 μg, 10 μg
  • Human IL31 Protein, hFc Tag [orb1290941]

    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

    The protein has a predicted molecular mass of 42 kDa after removal of the signal peptide. The apparent molecular mass of IL31-hFc is approximately 35-55 kDa due to glycosylation.

    Mammalian

    50 μg, 10 μg, 100 μg
  • Human IL31 Protein, His Tag [orb2321287]

    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

    The protein has a predicted molecular mass of 17.2 kDa after removal of the signal peptide.

    Mammalian

    10 μg, 100 μg, 50 μg
  • Human IL31 protein [orb595098]

    Greater than 85% as determined by SDS-PAGE.

    19.7 kDa

    Baculovirus

    1 mg, 20 μg, 100 μg
  • Human IL31 protein [orb604981]

    Greater than 85% as determined by SDS-PAGE.

    20.6 kDa

    E.coli

    20 μg, 100 μg, 1 mg