IKZF1 antibody

• Catalog Number: orb67129
• Category: Antibodies
• Description: Rabbit polyclonal to IKZF1.Ikaros family zinc finger protein 1 (IKZF1) is a transcription factor that belongs to the family of zincfingerDNA binding proteins associated with chromatin remodeling. The expression of IKZF1 isrestricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator oflymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoformshave been described for this gene. All isoforms share a common C-terminal domain, which containstwo zinc finger motifs required for hetero-or homodimerization and for interactions with other proteins.The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and thenuclear localization signal, resulting in members with and without DNA-binding properties. Only a fewisoforms display high affinity binding to a specific core DNA sequence element in the promoters oftarget genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought tofunction as dominant negative factors. Overexpression of some dominant-negative isoforms havebeen associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: middle region of human IKZF1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 58
• UniProt ID: Q13422
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-IKZF1 antibody,anti-DNAbinding protein Ikaros
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela using IKZF1 antibody