IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST)

• Catalog Number: orb1953758
• Category: Proteins
• Description: IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 63.1 kDa and the accession number is F8V4V0-1.
• Tag: His, GST
• Purity: 98.00%
• UniProt ID: F8V4V0
• MW: 63.1 kDa (predicted)
• Application notes: A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
• Expression System: E. coli
• Biological Origin: Streptococcus pyogenes
• Biological Activity: IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 63.1 kDa and the accession number is F8V4V0-1.
• Expression Region: A DNA sequence encoding the streptococcus pyogenes IdeS (F8V4V0-1) (Asp30-Asn341) was expressed with the N-terminal polyhistidine-tagged a GST tag at the N-terminus (his-GST) Predicted N terminal: Met
• Storage: -20°C
• Note: For research use only