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| Catalog Number | orb257899 |
|---|---|
| Category | Proteins |
| Description | Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53. |
| Reactivity | Human |
| Tag | C-Fc |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 40.4 kDa |
| Target | TRAIL R2 |
| Protein Sequence | NP_003833 |
| Source | Human TRAIL R2, Fc Tag (orb257899) is expressed from human 293 cells (HEK293). It contains AA Ile 56 - Glu 182 (Accession # NP_003833). |
| Expression System | HEK293 |
| Expression Region | Ile 56 - Glu 182 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_003833 |
| Storage | -20℃ |
| Buffer/Preservatives | 50 mM Tris, 100 mM NaCl, pH7.5 |
| Alternative names | TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2 Read more... |
| Note | For research use only |
| Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
Mettler Izquierdo, Shelley et al. High-efficiency antibody discovery achieved with multiplexed microscopy Microscopy (Oxf), 65, 341-352 (2016)
SDS-PAGE analysis of Human TRAIL R2 protein
- Item 1 of 1
Human TRAIL R2 / DR5 / TNFRSF10B Protein [orb257898]
Unconjugated
95%
15.4 kDa
Human TRAIL R2, His Tag (orb257898) is expressed from human 293 cells (HEK293). It contains AA Ile 56 - Glu 182 (Accession # NP_003833).
1 mg, 100 μg 
Biotinylated Recombinant Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avi His Tag [orb1550357]
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC
KMP2132, Biotinylated Recombinant Human TRAIL R2 / DR5 / TNFRSF10B Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ile56-Glu182) of Human TRAIL R2 / DR5 / TNFRSF10B fused with His Tag and Avi tag at the C-terminal.
100 μg, 500 μgRecombinant Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avi His Tag [orb1550373]
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC
KMP2116, Recombinant Human TRAIL R2 / DR5 / TNFRSF10B Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ile56-Glu182) of Human TRAIL R2 / DR5 / TNFRSF10B fused with His Tag and Avi tag at the C-terminal.
100 μg, 500 μg
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