Human TRAIL R2 / DR5 / TNFRSF10B Protein

• Catalog Number: orb257898
• Category: Proteins
• Description: Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 15.4 kDa
• Target: TRAIL R2
• Protein Sequence: NP_003833
• Source: Human TRAIL R2, His Tag (orb257898) is expressed from human 293 cells (HEK293). It contains AA Ile 56 - Glu 182 (Accession # NP_003833).
• Expression System: HEK293
• Expression Region: Ile 56 - Glu 182
• Endotoxins: 1.0 EU per μg
• NCBI: NP_003833
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 16-18 kDa, 19-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human TRAIL R2 protein