Human TNFR2 Protein, His Tag

SKU: orb257880

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Description

TNF RI is also known as the p60 or p55 TNFR) and TNF RII (the p75 or p80 TNFR) are two distinct type I transmembrane glycoproteins that bind TNF with highaffinity.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B, respectively. Human TNF RII cDNA encodes a 461 amino acid (aa) residue precursor protein with a 22 aa putative signal peptide, a 235 aa extracellular domain, a 20 aa transmembrane domain and a 174 aa cytoplasmic domain. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFα action by competing with cell surface receptors in binding TNFα, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage–pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis.

Research Area

Disease Biomarkers

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.0 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	TNFR2
Reactivity	Human
Tag	C-6×His
Molecular Weight	26.0 kDa
Expression Region	Leu 23 - Asp 257
Purity	95%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Human TNFRSF1B Protein, His Tag [orb1743294]

Conjugation:	Unconjugated
Purity:	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
MW:	The protein has a predicted molecular mass of 26.0 kDa after removal of the signal peptide. The apparent molecular mass of TNFRSF1B-His is approximately 35-55 kDa due to glycosylation.
Source:	E.coli

Sizes Available: 100 μg, 50 μg, 10 μg

Recombinant Human BIRC2 Protein, N-His [orb2963587]
Applications:
ELISA, SDS-PAGE, WB
Purity:
>90% as determined by SDS-PAGE.
MW:
13.63 kDa
Sizes Available: 1 mg, 50 μg, 100 μg
Recombinant Human BIRC2 Protein, N-His [orb2963589]
Applications:
ELISA, SDS-PAGE, WB
Purity:
>90% as determined by SDS-PAGE.
MW:
10.93 kDa
Sizes Available: 1 mg, 50 μg, 100 μg
Recombinant Human BIRC2 Protein, N-His [orb2963591]
Applications:
ELISA, SDS-PAGE, WB
Purity:
>90% as determined by SDS-PAGE.
MW:
71.01 kDa
Sizes Available: 1 mg, 50 μg, 100 μg
Recombinant Human BIRC3 Protein, N-His [orb2965862]
Applications:
ELISA, SDS-PAGE, WB
Purity:
>90% as determined by SDS-PAGE.
MW:
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Sizes Available: 1 mg, 50 μg, 100 μg

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SDS-PAGE analysis of Human TNFR2 protein

Quick Database Links

Gene Symbol

TNFR2

UniProt

AAA36755

RefSeq:AAA36755

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	AAA36755

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