Human S100A8 Protein

• Catalog Number: orb257818
• Category: Proteins
• Description: S100 calcium binding protein A8 (S100-A8) is also kown as Cystic fibrosis antigen, Migration inhibitory factor-related protein 8 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF and P8, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are known to be overexpressed in certain species of carcinomas. S100A8 may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. S100A8 plays an important role in differentiation of thyroid carcinoma possibly by forming a complex with S100A9. S100A8 and S100A9 may also play a key role in inflammation-associated cancer.
• Reactivity: Human
• Tag: Native
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 10.8 kDa
• Target: S100A8
• Protein Sequence: AAH05928
• Source: Human S100A8, Tag Free (orb257818) is expressed from E.coli cells. It contains AA Met 1 - Glu 93 (Accession # AAH05928).
• Expression System: E. coli
• Expression Region: Met 1 - Glu 93
• Endotoxins: 1.0 EU per μg
• NCBI: AAH05928
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: S100A8,60B8AG,CAGA,CFAG,CGLA,CP-10,MRP8,NIF,P8
• Note: For research use only
• Application notes: This protein carries no "tag". The protein has a calculated MW of 10.8 kDa. The protein migrates as 12 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human S100A8 protein