Human PSGL-1 / CD162 Protein

• Catalog Number: orb640168
• Category: Proteins
• Description: P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 30.7 kDa
• Target: PSGL-1
• Protein Sequence: NP_002997.2
• Source: Human PSGL-1, His Tag (orb640168) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Cys 320 (Accession # Q14242-1).
• Expression System: HEK293
• Expression Region: Gln 42 - Cys 320
• Endotoxins: 1.0 EU per μg
• NCBI: NP_002997.2
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: PSGL1,CD162,SELPLG,Selectin P ligand
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.7 kDa. The protein migrates as 55-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.