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Catalog Number | orb750334 |
---|---|
Category | Proteins |
Description | P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG. |
Reactivity | Human |
Tag | C-10×His & C-Avi |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Biotin |
MW | 32.4 kDa |
Target | PSGL-1 |
Protein Sequence | NP_002997.2 |
Source | Biotinylated Human PSGL-1, His, (orb750334) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Cys 320 (Accession # Q14242-1). |
Expression System | HEK293 |
Expression Region | Gln 42 - Cys 320 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_002997.2 |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | PSGL1,CD162,SELPLG,Selectin P ligand Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (). The protein has a calculated MW of 32.4 kDa. The protein migrates as 55-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
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