Human Prolactin R / PRLR Protein

• Catalog Number: orb420092
• Category: Proteins
• Description: As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 26.3 kDa
• Target: Prolactin R
• Source: Human Prolactin R, His Tag (orb420092) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).
• Expression System: HEK293
• Biological Activity: Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxinat 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag with a linear range of 20-156 ng/mL (QC tested).
• Expression Region: Gln 25 - Asp 234
• Endotoxins: 1.0 EU per μg
• NCBI: NP_000940.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH7.5
• Alternative names: Prolactin R,PRLR,PRL-R
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. orb511283) at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. orb420092) with a linear range of 20-156 ng/mL (QC tested).