Human Prolactin R / PRLR Protein

• Catalog Number: orb420091
• Category: Proteins
• Description: As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 51.0 kDa
• Target: Prolactin R
• Source: Human Prolactin R, Fc Tag (orb420091) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).
• Expression System: HEK293
• Biological Activity: Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxinat 1 μg/mL (100 μL/well) can bind Human Prolactin R / PRLR Protein, Fc Tag with a linear range of 2-78 ng/mL (QC tested).
• Expression Region: Gln 25 - Asp 234
• Endotoxins: 1.0 EU per μg
• NCBI: NP_000940.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: Tris with Glycine, Arginine and NaCl, pH7.5
• Alternative names: Prolactin R,PRLR,PRL-R
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. orb511283) at 1 μg/mL (100 μL/well) can bind Human Prolactin R / PRLR Protein, Fc Tag (Cat. No. orb420091) with a linear range of 2-78 ng/mL (QC tested).