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| Catalog Number | orb257715 |
|---|---|
| Category | Proteins |
| Description | Noggin is also known as NOG，SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus. |
| Reactivity | Human |
| Tag | C-Fc |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 49.2 kDa |
| Target | Noggin |
| Source | Human Noggin Protein, Fc Tag, premium grade (orb257715) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Cys 232 (Accession # Q13253-1). |
| Expression System | HEK293 |
| Expression Region | Gln 28 - Cys 232 |
| Endotoxins | 0.1 EU per μg |
| NCBI | NP_005441 |
| Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
| Buffer/Preservatives | PBS，pH7.4 |
| Alternative names | Noggin,NOG,SYM1,SYNS1 Read more... |
| Note | For research use only |
| Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
Ye, Junqing et al. Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds Cell Res, 26, 34-45 (2016)
SDS-PAGE analysis of Human Noggin protein
Human Noggin (C-Fc) Protein [orb1471746]
Unconjugated
Greater than 95% as determined by reducing SDS-PAGE.
50.2 KDa
Mammalian
50 μg, 10 μgHuman Noggin protein [orb80092]
FA, HPLC, SDS-PAGE
Unconjugated
> 95.0% as determined by SDS-PAGE.
500 μg, 100 μg, 5 μgRecombinant Human Noggin Protein [orb1550440]
> 95% by Tris-Bis PAGE
KMP2049, Recombinant Human Noggin Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln28-Cys232) of Human Noggin fused with no tag .
500 μg, 100 μgRecombinant human Noggin Protein, His Tag [orb1551133]
> 85% by SDS-PAGE.
KMP1354, Recombinant human Noggin Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Gln28-Cys232) of human Noggin (Accession #NP_005441.1) fused with a 6×His Tag at the C-terminus.
50 μg, 100 μg
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